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A facile synthesis of (±)-baclofen and (±) rolipram via fe(acac)3 catalyzed michael addition reaction

Author:

Manojkumar U. Chopade (s) and Anil U. Chopade, Harshal S. Patil

Subject Area:

Physical Sciences and Engineering

Abstract:

An effective and convenient procedure for the Michael Addition using Fe (acac)3 (5 mol %) as an effective catalyst, catalyses the Michael addition reaction of nitro methane to Chalcone to produce corresponding γ- nitro ketone derivatives with good yields (85-95 %) under mild condition with high yield. Accordingly, we applied this synthetic strategy for synthesis of (±)-Baclofen and (±)-Rolipram. Reaction Conditions: a) Chalcone (0.82 mmol), Nitromethane (2) (4.10 mmol), 5 mol % Fe(acac)3, anhy. DMSO (2mL), rt.

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