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ffect of Adansonia digitata fruit pulp extract on weekly glucose level in Alloxan induced diabetic rats

Author: 
Hauwa, S.M., Modibbo, A.A., Bello, H. and Sudi, P.D.
Subject Area: 
Life Sciences
Abstract: 

This study was designed to evaluate the anti diabetic activity of aqueous extract of Adansonia digitata fruit pulp in alloxan induced diabetic rats. Phytochemical screening, promate and elemental analyses of Adansonia digitata fruit pulp were determined. Alloxan was used to induce diabetes in diabetic groups at concentration of 8 0 mg/kg body weight intraperitonially. Albino rats were divided into seven groups, the first three groups serve as normal, diabetic and metformin controls while the remaining were treated with 100, 200, 500 and 1000 mg/kg body weight of Adansonia digitata fruit pulp aqueous extract for a period of 28 days and weekly glucose levels were determined. Phytochemical screening shows the presence of saponins, tannins, flavonoids, glycosides and absence of rennins and alkaloids. Proximate analysis showed high content of carbohydrate, (78.8 %), moisture (6.5 %), crude fiber (5.7 %), ash (5.5 %), protein (3.2 %) and fat (0.3 %). Adansonia digitata fruit pulp contain high concentration of potassium, calcium, magnesium, iron and low concentration of copper, lead and cadmium were not detected. There was significant increased in diabetic control of glucose level. Groups treated with Adansonia digitata fruit pulp extract and metformin significantly reduced. The highest activity of the extract was observed at concentration of 500 mg/kg body weight which posses 61.5 % activity of metformin drug. The finding of this study suggests that Adansonia digitata fruit pulp extract posses a hypoglycaemic effect at 500 mg/kg boy weight, therefore it can be used in management of diabetes mellitus.

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