Formulation and evaluation of mouth dissolving tablet of bendroflumethiazide

In the present research work, mouth dissolving tablets of bendroflumethiazide were prepared by direct compression method with a view to enhance patient compliance. Mouth dissolving tablets have many numbers of advantages over the conventional tablets like rapid disintegration, faster dissolution, Ease of administration and quick onset of action etc. Two super-disintegrants, viz., croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose along with mannitol to enhance mouth feel. Many pharmaceutical dosages are administered in the form of pills, granules, powders, and liquids. Generally, a pill is designed for swallowing intact or chewing to deliver a precise dosage of medication to patients. The drug and excipient interaction study was carried out by taking Infrared Spectrum of Pure drug and optimized formulation (B2). There was no change in the prominent functional groups of indicating drug is in intact form. The prepared batches of tablets were evaluated for hardness, friability, drug content, wetting time, water absorption ratio, disintegration time and dissolution study.