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Formulation and evaluation of mouth dissolving tablets of amiodarone hcl by using natural superdisintegrants

Author: 
Mohammed Ismail, Dr. Shaik Kareemulla, Mohamed Abdul Raheem, Mohammed Ahmed, Shafiq Ur Rahman Khalid, Shaik Gouse Basha and Zoheb Anjum
Subject Area: 
Health Sciences
Abstract: 

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery. Development of new drug molecule is expensive and time consuming. Improving safety efficacy ratio of “old” drugs has been attempted using different methods such as individualizing drug therapy, dose titration, and therapeutic drug monitoring. The conventional dosage forms (tablet and capsule) have wide acceptance up to 50-60% of total dosage forms. Tablet is still most popular conventional dosage forms existing today because of ease of self administration, compact in nature, easy to manufacture and it can be deliver in accurate dose. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. Amiodarone HCl is a white to cream-colored crystalline powder. It contains 37.3% iodine by weight. Tablet disintegration has been considered as the rate limiting step in faster drug release. Natural gums and mucilages have been widely explored as pharmaceutical excipients. These are widely used in the pharmaceutical industry as thickener, emulsifier, stabilizer, gelling agent, granulating agent, suspending agent, binder, film former, disintegrant and as sustained release matrix.

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