Formulation and evaluation of sustained release mucoadhesive microspheres of lansoprazole sodium

The Drug Lansoprazole has short half-life and hence requires frequent administration. Therefore the possible way for formulating a sustained release formulation of Mucoadhesive Microsphere. These formulation are prepared by Ionic gelation techniques by using polymer Sodium Alginate and Tragacanth. Various evaluation parameters are assessed, with a view to obtain sustained release of Lansoprazole. In the present study six formulations are formulated by using Sodium Alginate and Tragacanth various proportions. The prepared Lansoprazole microspheres are then subjected to IR, SEM, particle size and size distribution, % yield, Swelling Index, Micrometric, in vitro dissolution studies. The IR Spectra revealed that, there is no interaction between the polymer and Lansoprazole. Lansoprazole microspheres is spherical in nature, which was confirmed by SEM. Lansoprazole microspheres with normal frequency distribution are obtained. The in vitro release profile of Lansoprazole microspheres showed that sustained release is dependent upon the polymer concentration.