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Formulation development and evaluation of anti-diabetic drugs

Author:

Manogar, M. and Jayanthi Bangaru

Subject Area:

Life Sciences

Abstract:

The purpose of this research is to prepare metformin HCL500mg and vildagliptin 50mg immediate release tablets by wet granulation method. In order to obtain the best optimized product six different formulation were developed, disintegrants and lubricants using crosscarmellose sodium as super disintegrating agent . thickness, hardness, friability, disintegration time, in-vitro drug release and pharmaceutical assay were studied as response variable, the formulation F6 was selected as optimized formulation , the dissolution profile and the stability study of the formulated product also complies with ICH guidelines in the initial two months, optimization has proven an effective tool in product development.

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