We are reporting a case of HIV 2 infection from Kolkata, West Bengal, India. There are case reports of HIV 2 infection from western and southern parts of India, but reports from Eastern India are rare. Also this is an isolated case of HIV 2 infection in which diagnosis to death was very rapid. The patient was admitted with a diagnosis of HIV-2 infection and CD4 count of 42. He was diagnosed to have Pulmonary Tuberculosis and anaemia. The patient was discharged with proper treatment. He was admitted after one month with extreme deterioration in his condition and some more opportunistic infections. He succumbed. Total period of contact with us from diagnosis of HIV-2 to death was a little above one month.