
Abstract: Mucormycosis is a significantly lethal infection affecting immunocompromised individuals. We report a case of Sino-orbital-cerebral mucormycosis in a middle aged diabetic lady post renal transplantation. Materials and methods: A 47year old lady, diabetic since twenty years and underwent renal transplantation 6 months back for chronic renal failure, presented with history of loss of vision in the right eye of two hours duration. On examination, her vision was perception of light negative. She had total ophthalmoplegia and with severe proptosis. A clinical diagnosis of orbital apex syndrome was made. Results: An MRI showed invasive sinusitis with cerebritis, orbital cellulitis with proptosis, thickening of extraocular muscles, inflammatory changes in extraconal and intraconal fat. She underwent Maxillary antrostomy and lavage. Following surgerythe patient went into sepsis and could not be revived. Conclusion: Sino orbital cerebral mucormycosis is a potentially sight and lifethreatening complication in immunocompromised individuals.