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Gastro-renal interface in pathophysiology of hypertension

Author: 
Dr. Mohd. Nawaz, Dr. Ankita Prakash, Dr. Rashmi prakash and Dr. Nitin Ashok John
Subject Area: 
Health Sciences
Abstract: 

There has been an increase incidence of hypertension and metabolic disorders in the community of people of both developed and developing countries. The complications of hypertension at times are coupled with those of patients of diabetes and obesity. Neuropathy, retinopathy, autonomic dysfunctions and nephropathy are the common complications in hypertension as well as diabetes mellitus. The changing life style and stress in jobs in this world of the surrival of the fitness further increase in incidence of hypertension in adult population is in evitable. In this context adequate preventive measures such as exercise, diet and life style modifications are in demanding state for management of these ailments. But understanding the root cause of especially causation of primary hypertension needs to be evaluated, understood and needs to be put into practice. Along with kidney there is increasing importance of the GI hormones in the regulation of sodium balance, and consequently on blood pressure as sodium homeostasis is the prime contributors towards raised Blood Pressure. The recent modern school of thought belief in the fact that the GI tract hormones and peptides regulate the autocrine functions of renal hormones and are critical in affecting renal functions including sodium excretion. Hence we decided to explore the literature and review the role of GI Tract hormones in regulating the blood pressure and its implication in management of blood pressure. Increased understanding of the role of the gastro‐renal axis in the regulation of renal function may give us a novel insight into the pathogenesis of hypertension and provide a new treatment strategy for hypertension.

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