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Genetic studies in type2 diabetes in unani concepts of temperament; association between pro12ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 (PPAR-α) of Indian populati

Author: 
Seelamneni Thulasamma, Alokananda Chakraborty, Kaiser Jamil, Lahari Kuna, Shravan Ghali and Kazmi, M.H.
Subject Area: 
Life Sciences
Abstract: 

Background: Diabetes is a very common metabolic disorder among Indian population. This study validates some of the Unani concepts of humors or temperaments (Phenotypes), with regard to Type 2 Diabetes mellitus. We selected Damvi subjects for our study, with an aim to determine its association with the genetic biomarker- Peroxisome proliferator-activated receptor - Gamma (PPAR-γ) and other biochemical parameters. Methods: The Unani clinicians randomly selected 100 diabetic damvi patients who were attending the Unani hospital for treatment and 100 healthy volunteers belonging to damvi temperament. Institutional Ethics Committee approved the project. Besides looking at temperaments/ humors as susceptibility factors – we included a genetic factor-PPAR-γ to our investigation. We have genotyped the Proline 12 alanine (Pro12Ala C➝G) gene polymorphism by PCR-RFLP. Results: We found more of CC genotypes in both cases and controls and less number of the hetero genotypes CG in cases compared to controls. Interestingly the homo genotypes GG were not found in this group of patients as well as controls. In our study we observed a significant increase (p<0.001) in malondialdehyde (MDA) levels and GST levels using enzyme-linked immunosorbent assay (ELISA). We also found that plasma glucose levels (fasting and postprandial), total cholesterol, triglycerides, liver function tests and renal function tests were very high using Erba Autoanalyzer. Conclusion: We found that Damvi temperaments (Sanguine- Phenotypes) were more prone to T2DM; hence it is important that damvi phenotypes could be counseled to take preventive measures, also PPAR-γ and antioxidant levels have been identified as biomarkers for T2DM.

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