CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

 

 

 

 

 

 

 

 

 

 

 

Glycated hemoglobin and the activities of carbohydrate metabolic enzymes in the red blood cells of type 2 diabetic patients

Author: 
Thangarasu Rajakumar, Sekar Subashini, Mangipudi Ramakrishna Rao, and Kodukkur Viswanathan Pugalendi
Subject Area: 
Life Sciences
Abstract: 

Glycated hemoglobin (HbA1c) is one of the parameter to assess the diabetic condition. In this study, the activities of carbohydrate metabolic enzymes were assessed and correlated with HbA1c in the red blood cells (RBCs) of type 2 diabetes mellitus (T2DM) patients. Thirty diabetic patients (taking insulin and different antidiabetic drugs) from Rajah Muthiah Medical College and Hospital, between the age 40 and 70 were chosen and they were not suffering from any other illness and fifteen non-diabetic control subjects of the same age groups were also chosen for comparison. Index of glycemic control (plasma glucose, insulin, blood hemoglobin and glycated hemoglobin) and the activities of carbohydrate metabolic enzymes (hexokinase, phosphogluco isomerase, aldolase, pyruvate kinase and glucose 6-phosphate dehydrogenase) were measured. Diabetic patients have significantly higher plasma glucose, glycated hemoglobin and lower insulin and hemoglobin. Activities of hexokinase, phosphogluco isomerase, aldolase, pyruvate kinase and glucose 6-phosphate dehydrogenase were significantly lower in diabetic patients when compared with non-diabetic control subjects. Statistical analysis indicated a correlation of glycated hemoglobin with hexokinase (r= -0.858, p= 0.000), phosphogluco isomerase (r= -0.546, p= 0.000), aldolase (r= -0.591, p= 0.000), pyruvate kinase (r= -0.360, p= 0.023) and glucose 6-phosphate dehydrogenase (r= -0.449, p= 0.004) in non-diabetic control subjects and diabetic patients. Inspite of regular intake of antidiabetic drugs or insulin, the index of glycemic control showed significant increase implying impaired control of diabetes mellitus. Hexokinase showed a significantly strong negative correlation to glycated hemoglobin. RBCs hexokinase activity has been inversely correlated with glycation which could act as an index in evaluation of glycation in diabetic condition.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

 

 

 

 

 

 

 

 

 

 

 

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran