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Gstt1 gene a protective factor form chronic myeloid leukemia among sudanese population

Author: 
Elharam Ibrahim Abd allah, Khallafalla Ali khallafalla, Amr Galal Balla, Galia Zakaria Abdalnabi and Abdel Rahim Mahmoud Muddathir
Subject Area: 
Health Sciences
Abstract: 

Back ground: Interaction of environmental and genetic elements plays important role in the pathogenesis of CML and other types of cancer. Glutathione S-transferase (GST) is adetoxifying enzyme. Absence or low levels of this enzyme may genetically predispose individuals to CML. The aim of the present study was to determine GSTT1 Polymorphism among Sudanese patients with Chronic Myeloid Leukemia (CML) attending Radiation and Isotope Center-Khartoum. Materials and methods: Cross sectional case control study was conducted between January 2016 and August 2016 , on 50 patients with chronic myeloid leukemia among both genders at different ages admitted to Radiation and Isotope Center-Khartoum and 50 apparently healthy control subjects. The GSTT1 genotype was determined using polymerase chain reaction (PCR) method Result: The percentage of GSTT1 null genotype in CML patients was significantly higher than control (OR = 4.00, 95% CI: 1.62 –9.82; p =0.001).while GSTT1 polymorphism shows no statistically significance with the CML phases and hematological parameters except with the TWBCs. Conclusion: GSTT1 may be a protective factor for CML, while the null genotype shows association with the developing of chronic myeloid leukemia.

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