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Hepatic antioxidant and lipid peroxidative efficacy of caralluma attenuata (wight) against antituberculosis drug rifampicin induced hepatotoxicity In male albino wistar rats

Author: 
Minnady Muthulingam
Subject Area: 
Life Sciences
Abstract: 

India is the largest producer of medicinal plants. The medicinal plants have very important role in the health of human beings as well as animals. Herbal drugs have gained importance and popularity in recent years because of their safety, efficacy and cost effectiveness. The Indian Traditional Medicine like Ayurveda, Siddha and Unani are predominantly based on the use of plant materials. The usage of medicinal plants for primary health care needs by millions of people in developing world is still occupying a prominent position. The aqueous extract of Caralluma attenuata leaves was investigated for its antioxidant and lipid peroxidative efficacy on antituberculosis drug rifampicin (1 g/kg) induced liver damage in male albino wistar rats. Antioxidant and lipid peroxidative activity was measured by using biochemical parameters such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione reductase (GR), glutathione-s-transferase (GST) and TBARS in liver. Oral administration of the aqueous leaf extract of Caralluma attenuata at the doses of (125, 250 and 500 mg/kg) to rifampicin treated rats produced significant antihepatotoxic effect by decreasing the level of TBARS and enhance the levels of antioxidant activity in liver. The effects aqueous leaf extract of Caralluma attenuata were comparable to standard drug silymarin. These results suggest that aqueous leaf extract of Caralluma attenuata have potential therapeutic value in the treatment of liver diseases, probably by its antioxidative efficacy in liver.

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