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Histological Effect Of Tunkabein Drink On The Liver And Stomach Of Adult Wistar Rats

Author: 
Eric, U. E., 2Okoye, F.B.C. and Owajaniro, M. G.
Subject Area: 
Health Sciences
Abstract: 

Tunkabein drink is the local name for a locally prepared alcoholic beverage made up of alcohol (ogogoro) and Phyllantusamarus. In some of the Ijaw Communities, especially Amassoma, Bayelsa State of Nigeria. Twenty four(24) adult wistar rats of both sexes weighing 171g-250g were used for the study. They were assigned to four experimental groups of six rats each;group A(high dose group), groupB (low dose roup), group C(alcohol group) and group D(control group).The rats were sacrificed at the 15th and 22ndday.Histological result of the liver reveals that animals in group A showed extension of the portal tract into the parenchyma of the tissue with the infiltration of inflammatory cells,group B showed inflammatory cell and slight presence of Mallory bodies, group C showed dilated sinusoid and numerous Mallory bodies while group D showed normal liver tissue. Histological result of the stomach reveal that animal in group A show gastritis and superficial erosion, while group B show cysticaly dilated gastric gland with edematous stroma, group C showed distorted gastric architecture and slightly atrophic gland, however group D show normal histology of the stomach. The varying degree of damage done to the liver and stomach is due to the masking effect of thevarious concentration of alcohol over Phyllantusamarus (hepatoprotective and gastroprotective). Tunkabein is both hepatoxic and gastrotoxic and thus chronic consumption should be avoided.

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