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Histological effects of aframomum melegueta on the spleen of adult wistar rats

Author: 
Obike H. I. Ezejindu D. N., Ezejindu C. N.
Subject Area: 
Health Sciences
Abstract: 

This work focuses primarily on investigating histological effects of Aframomum melegueta aqueous extract on the spleen of adult wistar rats following oral administration. Twenty wistar rats of weights 180 – 215kg were divided into four groups designated as A,B,C and D. Group A served as the control and were orally administered with 0.35ml of distilled water daily; the experimental groups B,C & D were orally administered with 0.55ml, 0.65ml and 0.75ml of Aframomum melegueta aqueous extract for twenty eight days respectively. Twenty four hours after the last administration, the animals were weighed, anasthetized under chloroform vapour and dissected. Spleen tissues were removed, weighed and trimmed down for histological studies. The final body weight of the experimental groups (B, C & D) increased significantly (P<0.001) with the control. The relative spleen weight of the experimental groups B,C & D statistically increased (P<0.001) with the control (A). Histological results showed normal spleen architecture in the experimental groups B, C, & D relative to the control (A). This study therefore suggests that consumption of Aframomum melegueta aqueous extract at different doses did not induce spleen of adult wistar rats.

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