Motivation is the force that transforms and boost up people productivity and performance in their jobs. Maximize an employee's motivation is essential and critical for human resources in health care sector to effectively achieve the organization's objectives and goal. However, this is a significant challenge to human resources in public and private sectors in Saudi Arabia's HR managers, due to the complexity of what motivates people to work well in Saudis. The objective of this research was to identify and discuss some factors that influence Saudis employees’ motivation on both public and private sector health Industry. A survey method was designed to collect data from 150 employees of public and private hospitals in Jeddah Saudi Arabia. Results indicated that a number of work related factors affected employees’ motivation. Public hospital employees were more motivated by work contents and experience more balance between work and family life, whereas, private hospital employees were more motivated by financial rewards, career development opportunities, and supportive environment, as shown in the literature cited and proved by our results. Consequently to these outcomes, some recommendations were offer to enhance employee work motivation in Saudis.