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Implications of alteration of serum trace elements in febrile seizures

Author: 
Nemichandra, S. C., Prajwala, H. V., Harsha, S. and Narayanappa, D.
Subject Area: 
Health Sciences
Abstract: 

Introduction: Febrile seizures is the most common type of seizure in infancy and childhood. Its pathogenesis is still ambiguous. Changes in serum levels of trace elements have been proposed to underlie febrile seizures. Aim: To determine implication of serum magnesium and zinc levels in the pathogenesis of febrile seizures. Method: This prospective, analytical, case control study was carried out from October 2015 to September 2016 on 164 pediatric population aged between 6 months to 5 years admitted in JSS hospital, Mysuru. 82 cases of febrile convulsions and 82 age matched controls (with fever and no convulsions) were taken for the study. Serum magnesium levels were estimated by Xydiyl blue method and serum Zinc by calorimetric method in fully automated chemistry analyzer. Data was statistically analyzed using independent t- test and Chi- square test. SPSS version 21.0 is used for all calculations Results: Mean serum zinc levels were 8.93± 2.01 µmol/Land 12.74±3.47 in cases and controls respectively. Mean serum magnesium levels in cases and controls were 2.13± 0.46 mg/dl and 2.61± 0.54 respectively. Both the differences were statistically significant. Conclusion: Our study infers that deficiency of trace elements may be significantly related to the risk of febrile seizures in children.

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