Background: There was still a controversial effect of coffee, whether coffee could increase or decrease the blood uric acid level. Study about the influence of coffee on the blood uric acid level has never been conducted in Indonesia. Objective: To prove that coffee could decrease uric acid level in the hyperuricemia blood serum of rat. Method: A pre and post test design has been done on 24 wistar strain rats that were divided randomly into 4 groups. On the 1st and 2nd week all groups were fed high purin diet. On the 2nd week all group were given coffee, too. Group 1 were given 0.36 ml coffee solution/ day, the other group were given 0.72 ml/ day; 1.14 ml/ day and 2.16 ml/ day. Blood were drawn at the beginning before high purin diet were given, before and after coffee treatment. The blood uric level were examined using spectrophotometry. Data were analyzed using Pair- t test and One Way Anova. Results: There were decreased blood uric acid level in the group receiving 0,72 ml /day and 2,16 ml coffee solution/day. Conclusions: Coffee is able to reduce blood uric acid level in experimental rats.
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