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Influence of integrase inhibitor (raltegravir) on the pharmacodynamic activity of sitagliptin in animal models

Author: 
Lakshmi Thakkalapally, Sagar Pamu and Balakrishna Vuyyala
Subject Area: 
Health Sciences
Abstract: 

The availability of potent combination of antiretroviral regimens has resulted in a dramatic reduction in HIV-1 associated morbidity and mortality in the developed world. However, HIV infection and treatment has been associated with the development of insulin resistance, glucose intolerance and diabetes. The aim of the present study was to evaluate the effect of raltegravir (antiHIV drug) on pharmacodynamic activity of sitagliptin (antidiabetic drug) in normal and diabetic rats with respect to insulin levels. Alloxan-induced diabetic model in rats has been used in this study. In normal rats and diabetic rats the levels of insulin were calculated at 3 hr and 8 hr. The insulin levels were found to be similar in the groups of sitagliptin control and after single dose and multiple dose treatment of raltegravir in normal rats. The insulin levels of diabetic rats did not reduce significantly in single and multiple dose treatment of raltegravir when compared to sitagliptin control. The results confirm the absence of pharmacodynamic interaction of sitagliptin with acute and chronic administration of raltegravir.

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