Initial management of frozen addict: An update

Frozen Addicts are one of the leading causes of death. The World Health Organization (WHO) lists 126 central nervous system disorders. Although the cause of frozen addict are unknown, each year approximately 1,90,000 people in the United States and 10,000 people in Canada will be diagnosed with a primary symptoms. Frozen addicts are the number two cause of disability in men age 40 and older. Only 31 percent of males and 30 percent of females survive/recover five to fifteen years following the diagnosis of primary symptoms. Enhancing the quality of life of people with frozen addict requires access to quality specialty care, clinical trials, follow-up care and rehabilitative services. Although genes that are linked to monogenic forms of Parkin’s disease a and other closely related neurodegenerative diseases are, at first glance, not related to a coo man cause , recent genetic, pathologic and molecular studies have strengthened the evidence that there is probably more “cross talk” between the different pathway, on several levels, then previously appreciated. These finding support the existence of common pathogenic mechanisms, protein aggregiation, mitochondrial dysfunction or oxidative stress, which had been suspected as major culprits of neurode generation for many years. This review tries to demonstrate that during routine office visits, neurologist failed to identify the presence of depression, anxiety, and fatigue more than half of the time failed to recognize sleep disturbance in 40% of patients. Awareness of likelihood under recognition of behavioral symptoms in PD should generate approaches to diagnostic accuracy and facilitate timely therapeutic interventions.