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Intravenous methylene blue- life saving in methemoglobinemia due to nitrobenzene poisoning

Author: 
Professor and Head. Dr. Mangala Sonavani Borkar, JRII. Dr. Shradha S. Runwal, JRIII. Dr. Vimlesh R. Pandey, Associate Professor. Dr. Gajanan A. Surwade and Assistant professor. Dr. Prashant T. Gajbhare
Subject Area: 
Health Sciences
Abstract: 

Nitrobenzene is a nitrite compound often used in polishes or solvents. Its toxic effects are due to its ability to induce methemoglobinaemia. The clinical presentation of this poisoning varies according to the concentration of methemoglobin level in blood. The importance of early identification of the compound on the basis of clinical suspicion corroborative with methemoglobin levels with timely intervention is required to prevent fatal outcome (Agrawal et al., 2011). Our case presented with history of consumption of unknown compound followed by vomiting,mild cyanosis and altered sensorium. On investigation, ABG was suggestive of decreased SpO2, methemoglobinemia and severe metabolic acidosis. The urgent institution of methylene blue as the specific antidote saved the patient’s life.

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