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Invitro antioxidant, anti-inflammatory, inovo anti-angiogenic activities and virtual screening of phyto constituents of chromolena odorata

Author: 
Zaver Somani, Rituparna Bhattacharjee, Medha Chodankar and Abhilash N.
Subject Area: 
Life Sciences
Abstract: 

Chromolena odorata roots are used by traditional healers in Western Ghats for treating inflammation and tumor suppression. Hence the study tries to validate the use, by invitro antioxidant, anti-inflammatory and inovo anti-angiogenic activities. Virtual screening of active constituents of C.odorata was done using admet SAR an online web tool followed by molecular docking using autodock. Plant extract had a total phenol content of 30mg/g GAE. In comparison to the standard Ascorbic acid plant extract exhibited significant antioxidant activity by scavenging DPPH (IC50 104μg) and ABTS ions (IC50 84μg), reducing Ferric ions (IC50 50μg) and a Total Antioxidant Capacity of 27.5 mg/g Ascorbic Acid Equivalent. Percentage protection of HRBC by 300mg of plant extract was equivalent to that of 200mg of standard Diclofenec indicating anti-inflammatory activity with an IC50 value of 70μg. In inovo anti-angiogenic assay 500mg of extract disrupted the process of angiogenesis. Virtual screening highlighted the possibility of Chalcone, Kaempferide, Tamarixetin and Eupatilin becoming leads in future anti-inflamatory and anti agiogenic drugs.

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