Levels of free fatty acid and role of lipid-peroxidation in pre-eclampsia as compared to normotensive pregnant women

Preeclampsia is a hypertensive disorder and is one of the most leading cause for maternal and fetal mortality in developing countries. Objective: To evaluate the levels of free fatty acid and lipid-peroxidation levels in pre-eclampsia. Methods: This study was carried out in 100 patients with pre-eclampsia and 100 healthy pregnant women (control group) during the third trimester of pregnancy. The serum free fatty acid was determined by Estimation of serum free fatty acids by NEFA C diagnostic kit (wako pure chemicals. Richmond VA). Lipid-peroxidation was determined by utley’s method. Results: In the present study the level of free-fatty acid and MDA level are significantly increased in pre-eclamptic pregnancy compared with normal pregnancy Conclusion: Higher level of Free-fatty acid and lipid-peroxidation in serum is a marker of oxidative stress which play important role in the etiopathaogenesis of preeclampsia in pregnancy.