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Lipid based drug delivery systems: A strategy for enhancing the oral bioavailability of poorly water-soluble drugs

Author: 
Irfan A. Mohammed and BhavinY. Gajera,
Subject Area: 
Life Sciences
Abstract: 

The poor oral bioavailability of manydrugs is mainly due to the poor aqueous solubility, chemical instability and preabsorptive metabolism. Numerous approaches have been developed for enhancement of oral bioavailability and are currently in the clinical application. Even though, some drugs do not meet the required clinical application due to the patient compliance and ineffective therapeutic levels. Vesicular delivery systems are considered as alternative delivery for the enhancement the bioavailability of this category of drugs. The enhanced bioavailability of the liphophilic drugs from the vesicular systems mainly due to the increased effective surface area of the drug in the presence of lipids, surfactants and co surfactants, enhanced lymphatic uptake, altered gastric motility and by virtue of their small particle size. Extensive literature is available for the properties, applications, and preparation and evaluation methods. This review mainly dealt with the reported drug loaded various vesicular systems such as liposomes, niosomes, lipid nanoparticles, self-emulsifying delivery system, nanosuspensions.

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