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Low serum magnesium levels in preterm labour

Author: 
Sabha Malik, Farhat Ali, Azhar un Nisa, Fida Mohamad and Liaqat Ahmad Malik
Subject Area: 
Health Sciences
Abstract: 

Background: Preterm delivery is defined as birth occurring prior to 37 completed weeks of gestation and is one of the major cause of neonatal death. The objective of the study was to verify the correlation between low maternal serum magnesium levels and preterm delivery so that the high morbidity and mortality related to prematurity could be reduced by early diagnosis of its deficiency and its correction. Methodology: A prospective case control study was conducted between January, 2017 to January 2018 at SKIMS maternity hospital. A total of 88 women were enrolled, 44 women with established preterm labour and 44 of comparable gestation who had come to the hospital for routine checkup. Results: Women in preterm labour had a significantly reduced magnesium level with the mean of 1.369 ± 0.190 mg/dl versus 2.004 ± 0.132 mg/dl for those who delivered at term number of patients with preterm labour who gave history of muscle cramp were significantly greater than those delivered at term. Percentage of patient with preterm labour belonging to low socioeconomic class was significantly higher. Conclusion: Serum magnesium level can be used as a fairly good tool for predicting preterm labour. rticle deals with the generation of monodisperse micro bubbles using a microfluidic device based on 3D printing. The micro bubbles play a role of carriers of biologically active compounds to act locally in the chosen region having the ultrasound as the drug-releasing agent from a known frequency. The micro bubbles are generated by the passage of gas (nitrogen) through an emulsion consisting of coconut oil, a surfactant, and water, forming individual outer shell layers consisting of sunflower oil. In the development of the work, micro bubbles with an average diameter of 23.50m with a dispersion of 1.1% were produced, which characterizes a population with a high degree of homogeneity. The Lupeol used was isolated from Maytenusacanthophylla (Celastraceae) plant leaves by phytochemical and spectrometric techniques, including methods in liquid chromatography and 1H and 13C magnetic resonance. The natural product Lupeol is recognized for presenting actions against inflammation, antitumor (prostate cancer), arthritis, diabetes, heart disease, kidney, and liver toxicity. The micro bubbles generated by the technique described above will be applied in in vitro assays to evaluate the behavior of tumor cells in the presence of a population of micro bubbles after collapse caused by the presence of a known ultrasonic frequency and intensity, allowing the interaction of diseased cells with the biologically active component.

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