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Magnesium and its role in changing the specific number and intensity of expression of gelatinase b in the tissues of the stomach in an experimental ulceration

Author: 
Rogova, L. N. and Shesternina, N. V.
Subject Area: 
Social Sciences and Humanities
Abstract: 

Purpose: To determine the role of magnesium in the changing of intensity of the expression of specific Gelatinase B in the gastric tissue in an experimental ulcer. Material and Methods: The experiment was performed on 24 white Wistar rats. The Acetate gastric ulcer was simulated according to Ocabe S. The Investigation of Gelatinase B by immunohistochemistry was performed by standard methods. The magnesium levels in plasma and lymph were determined with a special set (Lachema), while the content of magnesium in red blood cells was judged based on the reaction with titan yellow. The magnesium-containing composition was used for the correction of the magnesium level. Results and discussion: There is a negative relation between the decrease of magnesium in red cells from the subclavian vein and activity of gelatinase B and a positive relation between the decrease of magnesium in red cells from the subclavian vein and the area of the ulcer. Using of magnesium-containing composition causes the increase of magnesium in red blood cells and the decrease of the activity of gelatinase B and the area of the ulcer. Conclusions: The results shows the optimize role of magnesium in activity of gelatinase B in gastric tissue in case of the gastric ulcer.

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