The current study was conducted to assess the marital satisfaction and stress among bipolar patients. A total number of 60 patients, 30 men bipolar patients and 30 women bipolar patients were selected through convenient sampling from different hospitals of Faisalabad and Lahore, Pakistan. The participants were administered ENRICH Marital Satisfaction Scale (Blaine and Olson, 1993) and Holmes and Rahe Stress Scale (Holmes and Rahe, 1967) to measure the level of marital satisfaction and stress among Bipolar patients. The score on ENRICH Marital Satisfaction Scale and Holmes and Rahe Stress Scale among men and women Bipolar patients was compared. Pearson’s Product Moment correlation and the t-test were used correspondingly to assess the relationship between marital satisfaction and stress among bipolar patients and gender difference on marital satisfaction and stress among bipolar patients. It was found that there was a negative relationship (r = -0.76, p < .01) between marital satisfaction and stress. Moreover a significant difference was found between men and women patients on marital satisfaction and stress score, which indicated that men patients scored high on stress and obtained low scores on marital satisfaction, on the other hand females obtained high score on marital satisfaction scale and low scores on stress. Implications of study results are discussed.