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Measles-rubella (mr) vaccine induced acute conversion reaction: a coincidental occurrence

Author: 
Dr. Amee D. Pandya, Dr. Sapna Gupta, Dr. Supriya D. Malhotra and Dr. Pankaj Patel
Subject Area: 
Health Sciences
Abstract: 

A 14 year-old boy, without relevant previous history, completely asymptomatic before one day of MR (measles-rubella) vaccination, developed paroxysmal event of muteness, intermittent episodes of bilateral lower limb weakness with difficulty in walking, visual hallucinations and suicidal ideas and eventually developed Psychosis after a week of his dose of MR vaccination. EEG, MRI-Brain, MRI-Spine were normal. The diagnosis was confirmed as Acute Conversion Disorder possibly triggered due to MR vaccine. Patient was started on Tab. Clonazepam but his condition was not improved and on regular follow up, is put on Tab. Clonazepam, Tab. Risperidone and Tab. Amitriptyline for control of worsening of symptoms. It is suggested that in some cases, vaccination may be the triggering factor for autoimmune and neurological disturbances in genetically predisposed individuals and physicians should be aware of this possible association. The relationship between vaccinations and onset of serious neuropsychiatric diseases is certainly a coincidence rather than causality.

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