The combination of polyethylene glycol (pegylated interferon) interferon and ribavirin has been shown to be an effective treatment for chronic hepatitis C virus. In general, common side effects related to this combination therapy are mild and are well tolerated. However, peripheral neuropathy including mixed type of polyneuropathy related to PEG-interferon α-2a (pegylated interferon alfa-2a) is extremely rare. In the literature, few case of acute inflammatory demyelinating polyneuropathy related to PEG-interferon α-2a has been published previously.