Soft tissue sarcoma (STS)–Leimyosarcoma of the chest wall is a rare entity with dismal survival. Surveillance, Epidemiology and End Result a 5 year survival rate of STS was 81%, 56%, 15% for localised, regional and distant metastasis respectively. Here we present a 31 year man with chest wall leimyosarcoma who is treated with primary surgery and multiple metastasectomy along with six lines of chemotherapy. The outcome of these efforts has resulted in prolong survival with good performance status worth reporting.