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Neonatal sepsis–culture positive sepsis vs. clinical sepsis

Author: 
Purbasha Ghosh and Rabindra Nath Misra and Retina Paul
Subject Area: 
Health Sciences
Abstract: 

The incidence of sepsis is increasing globally, with high morbidity and mortality. Diagnosis of neonatal sepsis is still a clinical and laboratory challenge. Though blood culture is gold standard, it sometimes gives false negative result. So, judgement of clinical condition along with various investigations is important. Methodology: Blood culture, sepsis screen, biochemical markers, cerebrospinal fluid (CSF) study, radiology, MRSA (methicillin resistance Staphylococcus aureus) surveillance were carried out in this study. Results: One seventy (65.9%) were culture positive and 88 (34.1%) were culture negative out of 258 clinically suspected cases. Methicillin sensitive Staphylococcus aureus (MSSA) 66 (38.82%) was the commonest organism. Among 88 culture negative cases, 38(43.2%) babies were two or more sepsis screen tests positive, 40(45.5%) culture negative babies were with risk factors and 5 (5.7%) had radiological evidence of pneumonia. Conclusion: The clinical diagnosis of it remains difficult as the symptoms are non-specific. So, blood culture is mandatory. Other diagnostic tests also help in this situation.

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