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Neutrophil to Lymphocyte ratio (NLR) as an inflammation marker in patient with chronic tonsillitis

Author: 
Dr. Surajeet Basumatary, Dr. Sangeeta Deka and Dr. Deepjyoti Kalita
Subject Area: 
Life Sciences
Abstract: 

Introduction: Neutrophil to Lymphocyte ration (NLR) is being studied extensively as a viable and inexpensive alternative to many recognized markers of inflammation (e.g. Cytokines, TNF, ASO, Prolactin etc.). Most of these studies are around GI and other condition/surgeries. This is a study which is examining the role of NLR in chronic tonsillitis cases pre & post-tonsillectomy vis-à-vis other established markers of inflammation. Aim: To examine the performance of NLR as reliable marker of inflammation in chronic tonsillitis subjects pre and post tonsillectomy. Methods: Thirty Chronic tonsillitis subject’s various parameters viz, Total WBC, Hemoglobin, Hematocrit, Neutrophil, Lymphocytes, ASO, CRP, ESR & NLR was estimated and compared pre (oneday prior tonsillectomy) and post surgery (around 1 month after surgery). Data were statistically analysed for reliability of NLR as marker of inflammation. Results: Statistically significant reduction in TC, Neutrophil, Lymphocytes, CRP, ASO and ESR level was observed, post surgery. Significant rise in NLR value was recorded. A negative correlation was established between reduced ASO, CRP, ESR etc. with raised NLR level pre to post-surgery. Conclusion: NLR value can be as useful as other markers of inflammation (ASO, CRP etc) especially in monitoring surgical management of chronic tonsillitis cases or those undergoing tonsillectomy operations. However a large scale study with more subject is essential.

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