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Odontogenic keratocyst (okc) or keratocystic odontogenic tumor (kcot) - journey of okc from cyst to tumor to cyst again : comprehensive review With recent updates on who classification (2017)

Author: 
Deepak Passi, Deepika Singhal, Mahinder Singh, Vijay Mishra, Yoshi Panwar and Aanchal Sahni
Subject Area: 
Health Sciences
Abstract: 

The odontogenic keratocyst (OKC) is a dilemmatic odontogenic developmental cyst of oral and maxillofacial region which has gained very special attention since last two decades. It has characteristic histopathological and clinical features but still the cyst is very special due to its aggressive behavior and high recurrence rate. Many prior attempts have been made to classify these cysts from 1887 to finally WHO 2017. Previously classified under developmental odontogenic cyst of jaw by WHO in 1971 & 1992, OKC has been reclassified and renamed as keratocystic odontogenic tumor (KCOT) in the WHO classifications of head and neck tumors in 2005 due to its aggressive behavior, high recurrence rates and specific histological characterstics. But recently WHO classification of Head and Neck pathology (2017) re-classified KCOT back into the cystic category. Despite of many classifications and nomenclature, unfortunately, clinicians are still facing difficulties in understanding the true nature, identification and management of OKC. An attempt is hereby made to review various aspects of OKC with emphasis on recent nomenclature, recurrence, molecular aspects, and management of OKC.

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