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One-pot synthesis, antibacterial, dna photocleavage and sar studies of some fused 1,4-dihydropyridines via symmetrical hantzsch condensation
Subject Area:
Physical Sciences and Engineering
Abstract:
Fused carbo/heterocyclic 1,4-dihydropyridine (1,4-DHPs) derivatives have been synthesized using β-cyclodextrin an efficient catalyst in alcohol with high yields and purity under one-pot method. The structures of synthesized compound were established using 1H, 13C-NMR, IR, ESI-MS and elemental analysis. The synthesized fused heterocyclic 1,4-DHPs were found to exhibit potent antimicrobial activity as compared to carbocyclic 1,4-DHPs and these results were further supported by percentage structure similarity using Chem 3D software with the standard antibiotic drug (Cefixime). Moreover, heterocyclic 1,4-DHPs shows excellent DNA photocleavage potential using agarose gel electrophoresis.
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