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Oral cancer, carcinogenesis & role of Mirnas in OSCC: diagnostic, therapeutic, prognostic

Author: 
Dr. Sonalee Shah
Subject Area: 
Health Sciences
Abstract: 

Oral squamous cell carcinomas (OSCC) represent the most frequent of all oral neoplasms & in India, OSCC is the leading cancer in men and fifth common cancer in women. The five year survival rate of 60-80% for OSCC has not improved in the last 3 decades inspite of improvements in therapy strategies. Research on cancer tissues has revealed that there may be a link between molecular level and tissue level changes that drive malignant changes in the tissue and play a pivotal role in disease progression. Therefore, the somatic mutations can be used as biomarkers to diagnose oral or other tumours. Research indicates that, for high accuracy in identifying early disease onset in saliva, multiple biomarker candidates are needed. Biomarkers are objective indicators which play an important role in distinguishing between the presence or absence of disease by genomic, proteomic, or metabolomic expressions. Biomarkers include nucleic acids, proteins, peptides, enzymatic changes, antibodies, metabolites, lipids, and carbohydrates derived from body fluids. Biomarkers can be used for: patient risk determination, patient assessment, recurrence detection. They are classified according to various ways. It has been estimated that over 30% of protein-coding genes are regulated by miRNAs either by complementary binding of target mRNA or binding to imperfect complementary sites in the 3′ untranslated regions (3′UTR), leading to control of expression of these genes at the level of translation. MicroRNAs are important in tumourigenesis due to their proximity to chromosomal breakpoints and their dysregulated expression levels in many malignancies. The identification of aberrantly expressed miRNAs which disrupt the normal regulatory mechanisms in cancer cells is an important first step towards elucidating the details of miRNA-mediated oncogenic pathways, which are essential to know to significantly improve diagnosis, therapy, and prevention of the disease.

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