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Pathway mapping of proteins involved in multiple sclerosis and identification of novel proteins

Author: 
Ruchi Yadav and Samreen Rizvi
Subject Area: 
Life Sciences
Abstract: 

WASH in the urban areas Multiple sclerosis is an unpredictable potentially disabling disease that causes disruption of the myelin that insulates and protects nerve cells of spinal cord and brain and permits electrical impulses to be conducted along the nerve fiber with speed and accuracy. So this disease disrupts central nervous system by damaging or demyelinating the insulated covers of nerve cells. In this paper we have made network of interacting proteins of more than 300 interacting proteins identified from protein interaction database .Initially 14 proteins were identified from Uni Prot database that were involved in multiple sclerosis disease . Gene Cards database was used to study pathways of proteins involved in network and new network was made that classifies interacting proteins on the basis of pathways involves. We found Three proteins, APBB2, APBB3 and MMP15 having no information about pathway and disease in which they are involved. New Network was designed to predicted pathway of these novel proteins, APBB2, APBB3 and MMP15, network mapping shows that these proteins connects directly to LRP4, that belongs to GPCR Signaling in Alzheimer’s disease pathway. This suggests that these proteins are involved in multiple sclerosis and also other diseases like Alzheimer’s disease. Further work can be done to identify potential drug target and can be used for drug designing.

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