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Peppermint up-Regulated jmjd1b protein expression in Daudi culture cells

Author:

Yasuko Kitagishi, Yuri Nishimura, Hitomi Yoshida, Naoko Okumura, Mutsumi Murakami and Satoru Matsuda

Subject Area:

Health Sciences

Abstract:

JMJD1B is a promising molecule involved in tumor suppressor, whose gene loss or inactivation may lead to MDS and AML. The present study aimed to determine the effects of certain herbs and spices on JMJD1B expression. RT-PCR was used to quantify the expression level of the gene. Protein samples were then analyzed by Western blotting. Both RT-PCR and Western blotting revealed the up-regulation of JMJD1B expression in Daudi cells treated with ethanol extracts of Peppermint or Lemongrass. In conclusion, component(s) of certain herbs and spices may induce the up-regulation of JMJD1B.

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