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Potential risk factors for onset and fetal mortality in acute fatty liver of pregnancy

Author: 
Ngaujah Samuel, Chu Ran, Malide Minati and Koroma TheresaRuba
Subject Area: 
Health Sciences
Abstract: 

Background: Acute Fatty Liver of Pregnancy (AFLP) is a rare but potently fatal complication that occurs in the third trimester or the immediate postpartum period. It is a sudden catastrophic illness hence an obstetric emergency that is associated with a higher maternal and fetal mortality if diagnosis is hampered. Objectives: The aim of this study is to explore potential risk factors influencing fetal outcome and survival. Patients and Methods: A retrospective study of 33 patients with a diagnosis of Acute fatty liver of pregnancy between 2009 and 2014 in our institution (Qilu Hospital of Shandong University) was performed. Fetal outcome were analyzed under different variables using Windows Microsoft Excel 2010. Results: Average maternal age of these 33 women was 27.03 ± 4.85 years and average age of with mothers Intrauterine fetal death (IUFD) was 26.66±3.05 years. Mean gestational age was 35.5±2.8 weeks. AFLP was frequently seen in Gestational age less than 36 weeks, multigravids, primiparas, women carrying male fetuses and singleton pregnancies. Fetal death was frequent in nulliparous mothers and male fetuses. Conclusion: Gestational age less than 36 weeks, primigravidity, male fetus, singleton pregnancy might all be risk factors for fetal mortality, while multigravida, is a potential risk factor for AFLP onset. Nulliparity and male fetus might be potential risk factors for both AFLP onset and fetal mortality associated with AFLP.

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