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Preparation of fast dissolving oral films of new generation anti migraine drugs by solvent casting method

Author: 
Pavan Kumar Kothapuvari, Swati Rawat and Kishore Kumar Kadimpati
Subject Area: 
Health Sciences
Abstract: 

This review article overview the advancement in the oral dosage forms, application, formulation consideration, method of preparation, evaluation of new generation Anti migraine drugs. Fast dissolving oral films (FDOFs) have been introduced in the market recently as they provide convenience and ease of use over other dosage forms such as orally disintegrating tablets. This technology evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers, so FDOFs are gaining the interest of large number of pharmaceutical industries. Fast dissolving oral films is the type of drug delivery system which when placed in the oral cavity, disintegrate or dissolve within few seconds without the intake of water. FDOFs are very similar to postage stamp in their shape, size and thickness. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. Migraine is a common, chronic disorder with episodic attacks9. It affects 10-20% of the population during the most productive periods of their working lives, women are affected up to four times more often than men. The present review provides an account of various formulation considerations, suitable method of preparation of the new generation Anti migraine drugs like Almotriptan malate and Eletriptan HBR into FDOFs.

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