The antibacterial activity of Moringa oleifera Aqueous and alcoholic leaf extract the highest concentration of extract is (100 mg/m l) and the lowest one is (12.5 mg/ml) against different four pathogenic organisms Bacillus cereus pseudomonad aeruginosa, Escherichia coli and Salmonella typhimurium were carried out by using a disc diffusion technique. In aqueous leaf extract of Moringa the highest antibacterial activity was detected against Escherichia coli in all different concentration of Moringa and the lowest inhibition zone against pseudomonad aeruginosa), In alcoholic leaf extract the highest antibacterial activity was detected against pseudomonad aeruginosa and Escherichia coli and the lowest inhibition zone against Salmonella typhimurium). The antibacterial activity of the synthetic antibiotics, (Ciprofloxacin, Tetracycline Ceftriaxone, Chloramphenicol and Gentamycin, were tested by the disc diffusion method, and by measuring zones of inhibition, shows that the highest activity of antibiotic against bacteria was due to the action of ciprofloxacin,. among all antibiotic and the lowest activity was due to the action of Tetracycline, the highest inhibition zone among the bacteria by antibiotic against Salmonella typhimurium and the lower inhibition zone against Bacillus cereus, all Aqueous and alcoholic leaf extract of Moringa have high activity against Escherichia coli, .so that there was no different between antibiotic and Moringa leaf extract against Escherichia coli and Bacillus cereus in this study.