Introduction: Stroke is a worldwide health problem. It makes an important contribution to morbidity, mortality and disability in developed and developing countries. Stroke is one of the leading causes of death after ischemic heart disease and malignancy. White blood cells are the cells of the immune system which protect the body against both infections and foreign invaders. An elevated white blood cell count may be caused either due to an infectious , inflammatory process .Present work was conducted to address the role of TLC in acute stroke patient and its correlation with severity and outcome. Materials and methods: It was Hospital based randomized case control observational study in which 50 Patients of acute ischemic stroke were enrolled as cases and 50 healthy age and sex matched individuals were enrolled as controls. The study was carried out between June 2019 and November 2019. Observation and Results: All these 50 patients of ischemic stroke confirmed by CT and MRI were classified on the basis of severity according to NIHSS stroke classification in mild (1-4), moderate (5-15), severe (16-20) and very severe (21-42) type of stroke. TLC level of all these patients were sent at the time of admission and mean TLC levels were calculated and it was compared with both the groups and correlated with severity and outcome. Conclusion: From our study it can be reasonably concluded that higher the levels of TLC, the greater will be the severity of stroke and poorer will be the outcome.
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