Protective role of [6]-paradol on dmba induced genotoxicity in male golden syrian hamsters

The present study designed to investigate the anti-genotoxic and detoxifying effects of [6]-paradol on 7, 12-dimethylbenz[a]anthracene (DMBA) induced genotoxicity in male golden Syrian hamsters. DMBA, a well known site specific carcinogen was given by intra peritoneal (i.p.) injection at the dose of 30 mg/kg b.wt. to induce acute toxicity in hamsters. A significant induction of chromosomal aberration, high frequency of micronucleus and altered levels of detoxifying agents status were recorded in DMBA treated hamsters. Oral administration of [6]-paradol at a dose of 30 mg/kg b.wt, through the gastric intubations for 5 days prior to DMBA treatment. However, the oral pre-treatment of [6]-paradol significantly improved chromosomal abberation, micronucleus frequency as well as improved the statuse of detoxification enzyme were recorded. Anti-genotoxic capacity of [6]-paradol probably due to presence of antioxidant principle and enhance the detoxifying enzyme activities.