CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Protective role of vitamin-e in manganese induced oxidative stress in rat cardiac tissue

Author: 
Bhuvaneswari Devi, C., Indravathi, G. and Kiran Kumari, K.
Subject Area: 
Health Sciences
Abstract: 

Oxidative stress is an essential biomarker in cell survival and death. Oxygen related radicals have a strong ability to cause long-term or even permanent damage to cellular components, particularly within the mitochondrial electron transport system (ETS). The present study addressed the effect of Manganese (Mn) on oxidative system in the cardiac tissue of rat. One month and three months old rats were exposed to Mn intraperitoneally at a concentration of low dose (2.5mg/kg body weight) and high dose (5mg/kg body weight) for a period of three weeks. A separate batch of low dose and high dose of Mn exposed rats received Vitamin-E intraperitoneally for a week. In this study, we assessed the biochemical end points indicative of oxidative stress and TCA cycle enzymes in mitochondrial fraction of cardiac tissue in rats at the age of two months and four months. We measured the activity levels of Mn-superoxide dismutase (Mn-SOD), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione dehydrogenase(GDH), succinate dehydrogenase (SDH) and isocitrate dehydrogenase (ICDH) which were decreased, whereas the lipid peroxidation (LP), glutathione-s-transferase (GST) showed significant increase in Mn exposed rats over control rats in a dose-dependent manner. The exposure to Vitamin-E, however, to low and high dose of Mn showed recovery which was observed in the increased activities of Mn-SOD, Cu/Zn-SOD, GPX, CAT, GDH, SDH, ICDH. Similarly, decreased levels of LP and GST were observed. The results may suggest that Mn-induced functional deficits in the oxidative enzymes of cardiac tissue and recovery through Vitamin E. As an antioxidant, Vitamin-E acts as a peroxyl radical scavenger, preventing the propagation of free radicals in tissues, by reacting with them and form a tocopheryl radical, which will then be reduced by a hydrogen donor and thus return to its reduced state. As it is incorporated into cell membranes, which protects them from oxidative damage. Thus Vitamin-E lesser the Mn burden in the cardiac tissue of rat as an effective chelating agent by decreasing the oxidative stress.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR

Rosane Cavalcante Fragoso, Brasil

ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran