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Relationship between h-ras oncogene and uterine cancer

Author: 
Majeed Hussein Majeed Al-Sarry
Subject Area: 
Health Sciences
Abstract: 

The current study is skillful to detect of the mutations of the H-RAS oncogene in patient of uterine cancer. Thirty specimens of blood and tissue were collected for DNA extraction, H-RAS oncogene amplification and histopathology examination. The results revealed to the present of mutations in H-RAS oncogene represented by homozygous wild type Leu / Leu was 20%, mutant translocation genotype Val / Val was 48%, mutant deletion genotype Val / Leu was 22% and heterozygous genotype Leu / Val was 10%. The histopathological results of this study reveal to many types of uterine cancer. The major types of uterine cancer that appear in this study represented by endometrial adenosquamous carcinoma that associated with endometrial lieomyosarcoma, the other cases were represented as endometrial spheriodal cell carcinoma and as endometrial intra epithelial carcinoma.

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