
Background: Patients with Diabetes mellitus (DM) develop low levels of High Density Lipoprotein (HDL) during the initial progression of disease. This study was aimed to analyze the relation of HDL with number of heavy meals per day in off springs of patients with type 2 DM. A large number of pathologies such as type 2 DM, obesity, Insulin resistance and Metabolic syndrome are associated with low and dysfunctional HDL Methods: A total of 120 cases and 120 controls completed the study. Cases and Controls were divided into three groups based upon the intake of number of heavy meals per day. Results: In group I, mean HDL of cases was 31.54± 7.96 where as that of controls was 49.58 ± 6.24. Similarly in group II, mean HDL of cases was 21.85 ± 4.52 where as that of controls was 49.28 ± 6.92. In group III, mean HDL of cases was 21.08±5.50 and of controls was 46.69± 4.57. Conclusions: There is a positive, significant and inverse relationship of HDL and number of heavy meals per day in the off springs of patients with type 2 diabetes mellitus; higher levels of HDL being associated with lesser intake of heavy meals and vice versa.