Introduction: Meningiomas are benign brain tumors in the brain wrapping tissue or meningens. The primary brain tumor most commonly diagnosed is meningioma, which is 33.8% of all primary brain tumors. Total resection of meningioma cases increases life expectancy and improves the prognosis of patients with these cases, in high grade meningioma total resection is not possible and another modality is needed to prevent tumor recurrence, including administering drugs to block the expression of genes that effect tumor growth.Initial studies show enzymes such as cysteine protease, metalloproteinase (MMP) and serine protease are closely related to growth and invasion of tumors. The Ki-67 antigenswere found in each active cell cycle (G1, S, G2 and M) but were not found in resting cells (G0). The expression of the Ki-67 protein is associated with the proliferative activity of the intrinsic cell population in malignant tumors, thus allowing its use as a marker of tumor aggressiveness. Method: This study is a cross sectional analytic observational research study in patients diagnosed as meningiomas in Adam Malik Hospital in the periods of January 2017 - December 2018.Inclusion criteria includes confirmed cases of meningioma by pathological examination and the patient's age is over 17 years. Exclusion criteria are based on medical record data, found other systemic diseases such as chronic obstructive pulmonary disease, arthritis, atherosclerosis, tubulointestial kidney disease and suffering from other tumors on the body.The sampling technique used is total sampling with a total sample of 33 samples. All meningioma paraffin block specimens that had previously been treated with hematoxylin-eosin base staining and confirmed as a meningioma had MMP-9 and Ki-67 immunohistochemical staining. After staining, overexpression of MMP-9 and Ki-67 labeling index (LI) were calculated. Results: The division of meningioma patient by gender is 23 women (69.7%) and 10 men (30.3%). The highest incidence of meningioma is in the age group of 40 - 49 years and equal to 18 cases (54.5%). While the least frequency of occurrence was found in the age group 60-69 namely 1 case (3%). the highest frequency is grade I meningioma in 24 (84.8%) cases, followed by grade II as many as 4 cases (12.1%) and grade III as much as 1 case (3%). The relationship between SI staining of MMP-9 and LI Ki-67, with Chi square analysis results with p value of 0.393. Conclusion: There is no significant relationship between MMP-9 overexpression with LI Ki-67
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