252 blood samples collected from patients of different localities of Allahabad region were found to be positive for typhoid fever when tested by Widal test. The causative agentSalmonella species were cultured from the blood samples and then were identified by using standard procedures. The isolates were identified as S. typhi, S. paratyphiA, S. typhimurium and S. bongori. Age, socio-economic status and seasonal variations were identified as significant risk factors associated with incidence of Salmonella infection. Blood samples were collected from both males and females belonging to the age groups from ˂1 to 50 years where the infection rate of typhoid fever was found to be higher among children. Socio-economic strata showed difference in incidence of Salmonella species with the low category showed highest number of isolates. Peak period of typhoid fever was found in June while a lower peak was noted in the month of November.