The role of bone marrow Mesenchymal stem cells in bone healing in Cranio-maxillofacial bone defects : A systematic review

Objective: The aim of this work was to review the literature about The role of bone marrow mesenchymal stem cells BMSCs in bone healing in cranio-maxillofacial bone defects. Design: Using related key words, electronic search of English-language papers was conducted on PubMed data-bases in Mars/2016. Studies that assessed the use of bone marrow mesenchymal stem cells BMSCs in bone regeneration in cranio-maxillofacial bone defects in human or animal models were included. The retrieved articles were thoroughly reviewed according to the in vivo experimental model, the cell carrier, the defect type, the method of evaluating and the obtained results. Results: A total of 24 articles were matched with the inclusion criteria of this study. Six articles were performed on rats, six on rabbits, six on dogs, two on pigs and four on human Conclusion: According to this review, the majority of the evaluated studies demonstrated positive results regarding the efficiency of bone marrow stem cells for in vivo bone regenerating.