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The role of lens malondialdehyde and gluthathione peroxidase activities in diabetic cataract and non diabetic cataract

Author: 
Masitha Dewi Sari, Delfi, Bobby Sitepu
Subject Area: 
Health Sciences
Abstract: 

Objective: Biochemical evidence suggests that oxidative mechanisms play a major role in the etiology and pathogenesis in damage of lens proteins is involved in the genesis of senile cataract and the degenerative manifestations of diabetes such as diabetic cataract. This damage decreases the antioxidant capacity results in oxidative damage Material and Methods: A prospective, analytical observational with cross sectional study was conducted at the Adam Malik Hospital from July 2016 to January 2017 after approved by the Ethics Committee for Health Research Sumatera Utara University School of Medicine. Fourty one diabetic cataract patients and fourty one non diabetic cataract patients of match age and gender were included in this study prospectively. Nucleus lens of malondialdehyde (MDA) and gluthathion peroxidase (GPx) who underwent cataract surgery were obtained to detect. Results: MDA levels in diabetic cataract ranges from 1.35 to 6.4 nmol/l, with a mean deviation of 2.48 ± 0.98 nmol/l, whereas MDA levels in non-diabetic cataract ranged from 0.52 to 2.62 nmol/l with a mean of 1.45 ± 0.47 nmol/l.GPx levels in diabetic cataract ranges from 1,77 to 15,66U/L, with a mean deviation of 5,82 ± 2,40U/L, whereas GPx levels in non-diabetic cataract ranged from 7,02 to 18,41U/L with a mean deviation of 9,52 ± 2,44μm/g. These results shows a significant differences MDA level and GPx level in diabetic caratact patients compare to non diabetic cataract patients.(p<0,05). MDA level and GPx level with the duration of Diabetes Mellitus showed significantly differences(p<0,05) Conclusion: Malondialdehyde and gluthathione peroxidase activities showed a decrement of antioxidant capacity in diabetic cataract that suggesting the implication of antioxidant enzymes in the genesis of diabetic cataract. Assays of malondialdehyde and gluthathione peroxidase activities could provide a marker to identify individuals predisposed to diabetic cataract

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