HIV infection is a global disease that disproportionately burdens populations with nutritional vulnerabilities. Selenium plays a key role in the maintenance of normal health in human population. It has been demonstrated that when taken as supplement selenium modulates the cellular response to oxidative stress, inducing a faster restoration of the endogenous anti oxidative defense system against the production of reactive oxygen species. Selenium that the body needs in order to maintain a responsive immune system, while selenium may also play a part in presenting HIV replication. An observational study was conducted on 150 HIV patients to observe the CD4 count among the patients at Government general hospital, Anantapuramu in which out of 150 HIV clients 100 (66.6%) were having high CD4 count with proportionate to their Selenium levels, remaining 50 (33.4%) clients were having low CD4 count as well as selenium levels.
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